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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Justification for selection of skin irritation / corrosion endpoint:
Only one study available.

Justification for selection of eye irritation endpoint:
Only one study available.

Effects on skin irritation/corrosion:slightly irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation / corrosion, other
Remarks:
The study is in vivo as the study already available based on literature already published.
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975=1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Due to absence of information on number of animal reliability category according to Klimisch is 3 (red score). Evaluator proposal is 2 (“reliable with restrictions”) because number of animals in compliance with method can be various.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no
Remarks:
The study was conducted in 1975 whereas OECD and EU Guidelines as well as GLP Principles were implemented in 1981 and 1988
Species:
rabbit
Strain:
other: New Zealand
Type of coverage:
other: intact and abraded skin
Preparation of test site:
shaved
Vehicle:
other: 50% paste with peanut oil prepared just prior to application
Controls:
other: 67% suspension of lactose in peanut oil was used
Amount / concentration applied:
50% paste with peanut oil
Duration of treatment / exposure:
24 and 72h
Observation period:
24 and 72h
Number of animals:
6 rabbbits with intact and abraded skin in each test groups
Remarks on result:
probability of mild irritation
Other effects:
A red pigment appeared on the skin after the TNT was applied (red color under all patches at 24h). Mild irritant.

Slightly irritating.

Interpretation of results:
GHS criteria not met
Conclusions:
Not irritating according to Regulation (EC) no 1272/2008 (CLP).
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation, other
Remarks:
The study is in vivo as the study already available based on literature already published.
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975-1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Due to absence of information on number of animal reliability category according to Klimisch is 3 (red score). Evaluator proposal is 2 (“reliable with restrictions”) because number of animals in compliance with method can be various.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no
Remarks:
The study was conducted in 1975 whereas OECD and EU Guidelines as well as GLP Principles were implemented in 1981 and 1988
Species:
rabbit
Strain:
other: New Zealand
Vehicle:
other: 50% paste with peanut oil prepared just prior to application
Controls:
other: 67% suspension of lactose in peanut oil was used
Amount / concentration applied:
50% paste with peanut oil
Duration of treatment / exposure:
24 and 72h.
Observation period (in vivo):
24 and 72h.
Number of animals or in vitro replicates:
6 rabbits per test groups.
Remarks on result:
no indication of irritation
Other effects:
Red pigment appeared around the eye after TNT was applied (red color around the eye at 24h). TNT did not produce eye irritation.

Not irritating.

Interpretation of results:
not irritating
Conclusions:
Not irritating according to Regulation (EC) no 1272/2008 (CLP).
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

The substance does not meet the criteria for classification as skin or eye irritant.