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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to
Guideline:
other: Microtox assay
Principles of method if other than guideline:
Microtox assay
GLP compliance:
not specified
Test organisms (species):
Vibrio fisheri
Test type:
static
Water media type:
brackish water
Total exposure duration:
15 min
Duration:
15 min
Dose descriptor:
other: IC20
Effect conc.:
> 0.3 - < 0.7 µmol/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 95% CL
Duration:
15 min
Dose descriptor:
IC50
Effect conc.:
> 2.8 - < 6.5 µmol/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 95% CL
Duration:
15 min
Dose descriptor:
LOEC
Effect conc.:
ca. 0.15 µmol/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 95% CL
Duration:
15 min
Dose descriptor:
NOEC
Effect conc.:
ca. 0.01 µmol/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 95% CL

IC50: 4.2 µmol/L (2.8 - 6.5 µmol/L)

NOEC: 0.01 µmol/L

Description of key information

Based on test results from publication nr 7.

NOEC: 0.01 µmol/L

TNT is 227.13 g/mol which is the same as 227.13 µg/µmol

NOEC is equal: 0.01 *227.13 = 2.2713 µg/L = 0.0022713 mg/L

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
2.271 µg/L

Additional information