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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

Algal growth inhibition: ErC50= 135 (127 – 143) mg/L; EyC50 = 81.3 (72.7 – 89.8) mg/L; NOEC = 32.0 mg/L

Key value for chemical safety assessment

EC50 for freshwater algae:
135 mg/L
EC10 or NOEC for freshwater algae:
32 mg/L

Additional information

Algal growth inhibition to the unicellular freshwater green alga Pseudokirchneriella subcapitata has been investigated according to OECD/EU test methods. 4 –MHHPA was found to inhibit the growth after 72 hours exposure, EC50-values with 95 % confidence intervals for inhibition of specific growth rate (ErC50) and yield (EyC50) being 135 (127 – 143) mg/L and 81.3 (72.7 – 89.8) mg/L, respectively.

In accordance with ECHA guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, theErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.