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EC number: 243-072-0
CAS number: 19438-60-9
Where possible, PNEC calculations have
been undertaken using default assessment factors in accordance with ECHA
guidance on information requirements and chemical safety assessment
Chapter R.10: Characterisation of dose [concentration] response for
PNECs were derived from the study with
the most sensitive species available for each compartment/endpoint. Acute
aquatic effects tests with fish, daphnids and algae showed no
significant effects and, in the case of fish and daphnids, LC50s were
not established. Other than effects on algae, no long-term effects data
are available on the substance itself. However, data are available on
structural analogues of the substance and these have been used in
deriving PNECs following adaptation of the NOECs to account for
differences in molecular weight.
Algae are the most sensitive species to the
toxic effects of 4 -MHHPA with an acute EC50 of 135 mg/L (based on
growth rate). Based on the results obtained in the aquatic toxicity
studies, 4 -MHHPA need not be classified regarding acute toxicity to the
Although 4 -MHHPA is not regarded as being
readily biodegradable, classification is not justified based on the low
toxicity observed in acute studies at three trophic levels, and low
potential for bioaccumulation.
Overview of Results used for
Classification and Labelling:
Fish, short-term, freshwater: LC50 > 100
Daphnia magna, short-term, freshwater: LC50
> 100 mg/L
Algae, freshwater: LC50 = 135 mg/L
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