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EC number: 243-072-0
CAS number: 19438-60-9
Acute immobilisation to Daphnia
growth inhibition to unicellular freshwater green alga and
acute toxicity to fish have been investigated. In Daphnia and fish no
effects were observed at a concentration of 100 mg/L. In algae,.4
–MHHPA was found to inhibit the growth after 72 hours exposure,
EC50-values with 95 % confidence intervals for inhibition of specific
growth rate (ErC50) and yield (EyC50) being 135 (127 – 143) mg/L and
81.3 (72.7 – 89.8) mg/L, respectively. In
accordance with ECHA guidance on information requirements
and chemical safety assessment, Chapter R.7b: Endpoint specific
guidance, the ErC50 endpoint is used in DNEL derivation. This is because
use of values based on biomass cannot be applied to an analysis of
results from a system in exponential growth without logarithmic
Toxicity to microorganisms has been
investigated in an activated sludge respiration inhibition test
according to OECD test methods. 4 –MHHPA caused a concentration related
inhibition ranging from 14% at 58 mg/L to 99% at 1000 mg/L. The EC50 was
219 (189 – 248) mg/L with concentrations of 95.3 mg/L and below causing
less that 20% inhibition and regarded as not toxic to microorganisms of
a municipal sewage treatment plant. EC10, estimated from reported EC20,
EC50 and EC80 values, was approximately 70 mg/L. Effects or pH on
inhibition were examined and found to be the major factor in determining
effects, a concentration of 1000 mg/L causing <20% inhibition when pH
was adjusted back to neutral.
No effects data following long-term
exposure are available on the registered substance itself. Reliable data
on fish are available for two structural analogues of the substance -
MTHPA and phthalic anhydride, with the best quality data being that from
an early life stage study with phthalic anhydride. The lower NOEC value
of 10 mg/L determined for phthalic anhydride was used as suitable
read-across value for 4-MHHPA considering a worst case approach. When
the NOEC of 10 mg/Lfrom this study is corrected for differences in
molecular weight, a calculated NOEC of 11 mg/L for 4–MHHPA is obtained.
Data from long-term studies on aquatic invertebrates are available on
three structural analogues of the substance, which after considering
differences in molecular weight, lead to comparable NOEC values. The
best quality data are that from a recent study with
methyl-tetrahydrophthalic anhydride (MTHPA). The NOEC from this study
was 20 mg/L which, when corrected for differences in molecular weight,
results in a calculated NOEC of 20 mg/L for 4-MHHPA. For a more detailed
read-across justification please refer to section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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