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EC number: 243-072-0
CAS number: 19438-60-9
The study was performed to assess the acute
dermal toxicity of the test material in the Sprague-Dawley strain rat.
The method used followed that described in the OECD Guidelines for
Testing of Chemicals (1981) No. 402 "Acute Dermal Toxicity" referenced
as Method B.3 in Commission Directive 84/449/EEC (which constitutes
Annex V of Council Directive 67/548/EEC).
A group of ten animals (five males and five
females) was given a single 24-hour, semi-occluded dermal application to
intact skin at a dose level of 2000 mg/kg bw. The animals were observed
for fourteen days after the day of treatment and were then killed for
gross pathological examination.
There were no deaths. No signs of systemic
toxicity were noted during the study. Very slight to well-defined
erythema was noted at the treatment sites of all animals. Other skin
reactions noted were haemorrhage of the dermal capillaries and crust
formation. Treatment sites appeared normal two to five days after
dosing. All animals showed expected gain in bodyweight during the study.
No abnormalities were noted at necropsy.
The acute dermal median lethal dose (LD50)
of the test material in the Sprague-Dawley strain rat was found to be
greater than 2000 mg/kg bodyweight.
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