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EC number: 701-008-3
CAS number: -
No in vivo genotoxicity data are available
on S278. A micronucleus test was performed to assess the potential of
the structurally related compound, di(isononyl) phthalate (DINP 1; CAS
68515-48-0), to induce chromosome aberrations in the bone marrow of
Briefly, young male mice (5/dose) were
administered DINP 1 by stomach tube at 0, 500, 1000, or 2000 mg/kg
bw/day on two consecutive days. On the third day the animals were
sacrificed, and slides were prepared from bone marrow erythrocytes. A
total of 1000 erythrocytes were counted from each animal, and the total
numbers of polychromatic (PCE) and normochromatic (NCE) erythrocytes
were tabulated. A total of 1000 PCEs were evaluated for the presence of
micronuclei in the treated group, and compared to that from the vehicle
control group (no further details given on identity and dose of vehicle
control) and the positive control group (receiving cyclophosphamide at
20 mg/kg bw/day).
Frequency of micronucleus formation was not
elevated at any dose in the treated animals compared to the vehicle
controls, and there was no evidence of toxicity (examination not
described) at up to 2000 mg/kg bw/day. Treatment with the positive
control induced a statistically significant increase in micronuclei
formation, confirming the sensitivity of the testing procedure.
In conclusion, DINP 1 was inactive in an in
vivo micronucleus test in which male mice (5/dose) were administered
this phthalate by stomach tube at up to 2000 mg/kg bw/day on two
consecutive days, and bone marrow erythrocytes were assessed for
micronuclei formation on the third day.
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