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EC number: 701-008-3
CAS number: -
Uniform distribution of vapour and aerosol within exposure chambers
throughout the study; >90% of particles were <10 µm;
some vapour existed at the high and mid exposure levels.
Urine-stained fur and chromodacryorrhea were
observed in both sexes in the mid- and high-exposure groups. Although
the investigators described these findings as "seemingly compound and
dose-related", the EU RAR made no mention of chromodacryorrhea but
stated that urine-stained fur, piloerection and alopecia "were not
considered as reliable indicators of the test compound". Increased
relative liver and kidney weights were seen at the top dose, and males
in this group had a marked decrease in serum glucose at terminal
sacrifice, leading the EU RAR to set a no-observed-adverse-effect
concentration (NOAEC) of 0.218 mg/l.
In a reliable study, an NOAEC of 0.218 mg/l
was established for rats exposed to BBP by inhalation for 6 hours/day on
5 days/week for 13 weeks. Increased relative liver and kidney weights
were observed at the higher test concentration of 0.789 mg/l, although
there were no accompanying histopathological findings.
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