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Environmental fate & pathways

Adsorption / desorption

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Description of key information

The mean estimated log Koc for Santicizer 278 is 5.383.

Key value for chemical safety assessment

Additional information

Experimental adsorption/desorption data is not available for Santicizer 278. As the log Kow is >3 the adsorption/desorption endpoint cannot be waived. However, ECHA's Guidance on Information Requirements and Chemical Safety Assessment R7a Endpoint Specific Guidance (2008) indicates that before commissioning a new study alternative sources of data (e.g. QSAR) on the adsorption/desorption potential of a chemical should used.

Soil sorption of non-ionic substances can be estimated from their log Kow. Several QSAR have been developed that calculate the Koc of non-polar hydrocarbons on the basis of their log Kow. Two QSARs (the two methods of KOCWIN, USEPA 2008) have been used to calculate the log Koc of Santicizer 278. The estimated log Koc are 6.099 and 4.666, and the mean of these values will be used in the risk assessment.

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