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EC number: 701-008-3
CAS number: -
Undiluted Santicizer 278 was
administered to Sprague-Dawley rats (of either sex) by stomach tube at
2.0, 3.16, 5.01, 7.94 or 12.6 g/kg bw, and to 5 rats (3 male and 2
female) at 15.8 g/kg bw. The animals were assessed for toxic symptoms
and weight gain during the observation period, and the surviving animals
were sacrificed nine days after dosing and examined macroscopically.
All ten animals survived the nine day
observation period. Reduced appetite and slight weakness were seen for
one to three days (numbers of animals and doses not given), whilst
weight gain was described as "near normal". At necropsy, two rats had
haemorragic areas in the lungs, and all 6 rats receiving 12.6 g/kg bw
and above had gaseous intestinal tracts. The viscera of animals
receiving up to 7.84 g/kg bw appeared normal. The investigators
concluded that “the compound was classed as practically non-toxic by
oral ingestion in male and female rats”. Under the conditions of this
study, the acute oral LD50 can be considered greater than 2 g/kg bw (but
likely much higher). Under the EC CLP regulations, this study would
indicate that Santicizer 278 is not classified for acute oral toxicity.
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