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EC number: 701-008-3
CAS number: -
No toxicokinetic studies have been conducted
on Santicizer 278, however read-across information available for the
structurally related, high molecular weight phthalates DIDP (European
Chemicals Bureau, 2003a) and DINP (European Chemicals Bureau, 2003b)
provides useful supporting information. Metabolism proceeds via the
corresponding monoester and its oxidation products, with excretion
occurring primarily via urine and (to a lesser extent) faeces. Both are
recovered mainly from the gastrointestinal tract, liver and kidney
following oral administration whereas liver, muscle and adipose tissue
contain most of the retained dose after dermal exposure. However results
of repeated dosing studies with DINP demonstrated no bioaccumulation.
Uptake from the gastrointestinal tract appears a saturable process, with
the proportion absorbed decreasing with increasing dose (e. g. 56%, 46%
and 17% absorbed, respectively, following oral administration of 0.1,
11.2 or 1000 mg/kg bwt DIDP mg/kg; 49% and 39%, respectively, absorbed
of an oral dose of 50 or 500 mg/kg bw DINP). Dermal absorption of both
phthalates is quite low (uptake of less than 4% of the applied dose over
7 days) with bioavailability of around 75% following inhalation
exposure. For the purposes of risk characterisation of Santicizer 278,
50% absorption from the gut, 75% absorption after inhalation exposures
and 5% uptake by skin will be assumed.
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