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EC number: 701-008-3
CAS number: -
Undiluted Santicizer 278 was applied
to the closely clipped, intact skin of a total of five New Zealand white
rabbits. Three females were dosed at 2.51, 6.31 or 10 g/kg bw (one at
each dose), and two males at 3.98 or 10 g/kg bw. The treated areas were
covered with “plastic strips” and the animals held in wooden stocks for
periods of up to 24 hours, before being assigned to individual cages.
The animals were assessed for toxic symptoms and weight gain during the
observation period, and the surviving animals sacrificed 14 days after
dosing and examined macroscopically.
All five animals survived the 14-day
observation period. Reduced appetite was seen at 6.31 and 10 g/kg bw,
and slight weakness for two days at 10 g/kg bw. Growth during the 5 days
after dosing appeared unaffected by treatment, and the “viscera appeared
normal by macroscopic examination”. The investigators concluded that
“the compound was classed as practically non-toxic by skin absorption in
male and female rabbits”. Under the conditions of this study, the LD50
can be considered greater than 10 g/kg bw. Under
the EC CLP regulations, this study would indicate that Santicizer 278 is
not classified for acute dermal toxicity
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