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EC number: 701-008-3
CAS number: -
Undiluted Santicizer 278 (0.1 ml) was
placed in the conjunctival sac of the right eye of three albino rabbits,
and subsequently rinsed with warm saline after 24 hours. The treated
eyes were assessed for signs of irritation during the 7-day observation
period, and the data scored according to the method of Draize.
Immediately after rinsing, little or
no discomfort was observed. However, at 10 minutes and 1 hour after
rinsing, barely perceptible erythema and slight discharge was seen (but
no oedema), with an average score of 4 out of a possible 110 when
examined at 1 hour post exposure. Eyes were described as normal when
examined 24, 48, 72, 120 and 168 hours after rinsing. The investigators
classed the test material as a slight eye irritant in male and female
rabbits. Under the EC CLP regulations, this study would indicate that
Santicizer 278 is not irritating to the eyes.
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