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EC number: 701-008-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- In vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only available as a brief summary report
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The undiluted test material was applied (occluded) to the skin of rabbits for 24 hours, and the skin was subsequently assessed for signs of irritation over a period of a week.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction Mass of Benzyl (1R,1S) 2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl benzene-1,2-dicarboxylate and Benzyl (3R,3S) 2,2,4-trimethyl-3-[(2-methylpropanoyl)oxy]pentyl benzene-1,2-dicarboxylate
- EC Number:
- 701-008-3
- Molecular formula:
- C27H34O6
- IUPAC Name:
- Reaction Mass of Benzyl (1R,1S) 2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl benzene-1,2-dicarboxylate and Benzyl (3R,3S) 2,2,4-trimethyl-3-[(2-methylpropanoyl)oxy]pentyl benzene-1,2-dicarboxylate
- Reference substance name:
- Benzyl 3-isobutyryloxy-1-isopropyl-2,2-dimethylpropyl phthalate
- EC Number:
- 240-920-1
- EC Name:
- Benzyl 3-isobutyryloxy-1-isopropyl-2,2-dimethylpropyl phthalate
- Cas Number:
- 16883-83-3
- Molecular formula:
- C27H34O6
- IUPAC Name:
- Benzyl 2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl benzene-1,2-dicarboxylate
- Details on test material:
- Name of test material (as cited in study report): Santicizer 278
- Lot/batch No.: EL 9026
no further data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Probably New Zealand white
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- One week
- Number of animals:
- Two females and one male
- Details on study design:
- TEST SITE
- Type of wrap if used: "plastic strips" to retard evaporation and avoid contamination.
no further data
REMOVAL OF TEST SUBSTANCE
Test material removed after 24 hours, presumbaly by gentle washing but no details given.
SCORING SYSTEM: According to the method of Draize et al. (1944).
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- ca. 0.6
- Max. score:
- 8
- Reversibility:
- fully reversible within: 48 hours
- Irritant / corrosive response data:
- Barely perceptible redness was reported in two of the three rabbits examined 24-hours after removal of the test material, with an average maximum score of 0.6 out of a possible 8. No irritation was reported at the other time points (1, 48, 72, 120 and 168 hours after the end of exposure) with any of the three rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- A 24-hour covered application of undiluted Santicizer 278 was not irritating to the intact skin of three rabbits.
- Executive summary:
Undiluted Santicizer 278 was applied to the clipped, intact skin of one male and two female albino rabbits, covered with "plastic strips", and removed after 24 hours. The animals were subsequently assessed for signs of irritation during the 7-day observation period, and the data scored according to the method of Draize.
Barely perceptible redness was reported in two of the three rabbits examined 24-hours after removal of the test material, with an average maximum score of 0.6 out of a possible 8. No irritation was reported at the other time points in any of the three rabbits. The investigators classed the test material as non-irritating when applied (occluded) to the intact skin of male and female rabbits. Under EC CLP regulations, this study would indicate that Santicizer 278 is not irritating to the skin.
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