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EC number: 701-008-3
CAS number: -
Santicizer(R) 278 was
examined for mutagenic activity in five strains of S. typhimurium using
the plate incorporation test. The bacterial strains employed are capable
of detecting both induced frameshift (TA 1537, TA 1538 and TA 98) and
base-pair substitution (TA 1535 and TA 100) mutations. Tests were
conducted in triplicate with the test material in DMSO at levels from
0.01 to 10 mg/plate, both with and without the addition of S-9.
Revertant colonies per plate and toxicity were measured after at least
48 hours, and compared to the controls. Due to possible significant
increases in revertants/plate over controls, two retests (again in
triplicate) were conducted with the test material at 0.5, 1 and 1.5
S.typhimurium TA 100 (with S-9) and in TA 1537 (without S-9).
study does not entirely conform with current OECD guidelines which
recommend using S. typhimurium strain TA 102, or Escherichia
coli WP2 uvrA to detect cross-linking agents. In additon, the study
report does not describe how "toxicity" was determined, although it was
probably based on a thinning
of the background lawn of non-revertant cells.
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