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EC number: 248-948-6
CAS number: 28299-41-4
All dose groups: no changes of the hematological,
pathologic-anatomic, histopathological or ophthalmologic parameters.
5000 ppm : in the males body weight gain reduced by ca. 10 %;
in both sexes liver weights
increased, but Cytochrome P-450 and N- or O-Demethylases not induced;
clinical-chemical investigations: indications of a
treatment-related influence on the metabolism of proteins
(increased content of albumin and decreased content of
globulin in the serum) and indications of a slight
cholestasis (increased activities of the alkaline
phosphatase in the plasma).
Ten male and female rats each were administered orally daily doses of
the test substance of 0 (control), 550, 1650 or 5000 ppm (ca. 0, 45, 132
or 425 mg/kg bw/d - male rats; ca. 0, 56, 174 or 604 mg/kg bw/d - female
rats) via diet for 13 weeks.
At the end all animals were killed and necropsied; gross and microscopic
examination of: all major organs, including reproductive organs; in male
rats prostate, seminal vesicle, testis and epididymis; in female rats
mammary gland, uterus, and ovary.
NOAEL = 425 mg/kg bw/day (rats, male) and NOAEL = 604 mg/kg bw/day
(rats, female); the pathological examination revealed no difference
between the dosed and control groups.
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