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EC number: 248-948-6
CAS number: 28299-41-4
The toxicity to the terrestrial compartment of Ditolylether was
investigated in three long-term studies (earthworm, plants and
microogranisms) according to OECD TG 222, OECD TG 208 and OECD TG 216.
While no effect was exhibited in the N-transformation test on soil
microorganisms, effects were apparent in the earthworm reproduction test
as well as in the seedling emergence and growth test. The lowest NOEC
appeared in the seedling emergence and growth test with NOEC = 6.0 mg/kg
soil dry weight (Solanum lycopersicum); which is hence further used for
Toxicity to terrestrial invertebrates
The test substance Ditolylether was tested according to OECD Guideline
No. 222 for the Testing of Chemicals "Earthworm Reproduction Test
(Eisenia fetida/Eisenia andrei)" adopted July 29, 2016 with eisenia
fetida. The NOEC value for the endpoints mortality and reproduction
were the same with 50 mg/kg soil dw. So were the LOEC values for the
endpoints mortality and reproduction with 100 mg/kg soil dw,
respectively. Regarding mortality, a LC50 of 87.1 g/kg soil dw and
regarding reproduction a LC50 of 65.1 mg/kg soil dw are reported.
As the NOEC values for reproduction and mortality were the same, the
value of 50 mg/kg soil was chosen for the assessment, in accordance with
being the lowest value.
Toxicity to terrestiral plants
The effect of the test item Ditolyl ether on the emergence and growth of
six species of higher terrestrial plants was tested accordig to OECD
Guideline for the Testing of Chemicals No. 208; Terrestrial Plant Test:
Seedling Emergence and Seedling Growth Test. The test item had no
statistically significant effect on emergence except for Avena sativa
for which an EC10 of 294.8 mg/kg soil dry weight could be determined. An
effect on survival was seen with Allium cepa for which an LC10, LC50,
LOEC and NOEC could be determined and with Brassica rapa for which an
LC10 could be determined. No statistically significant effect on
survival could be observed in any of the other test species.
Shoot fresh weight was statistically significantly reduced at test item
concentrations of ≥18.0 mg/kg soil dry weight in S. lycopersicum, ≥54.0
mg/kg soil dw in B. rapa, and A. cepa, ≥72.0 mg/kg soil dw in C. sativus
and P. sativum, and ≥216 mg/kg soil dw in A. sativa.
The lowest values for the end points EC10, EC50, LOEC and NOEC were
observed with shoot fresh weight of the test species Allium cepa, Pisum
sativum and Solanum lycopersicum. The values were as follows:
EC10 = 8.8 mg/kg soil dry weight (Pisum sativum)
EC50 = 41.9 mg/kg soil dry weight (Allium cepa)
LOEC = 18.0 mg/kg soil dry weight (Solanum lycopersicum)
NOEC = 6.0 mg/kg soil dry weight (Solanum lycopersicum)
Toxicity to soil microorganisms
The test item Ditolyl ether, was tested in accordance with OECD
Guideline for the Testing of Chemicals No. 216 “Soil Microorganisms:
Nitrogen Transformation Test".
Nitrate concentration in test-item treated soil measured on day 0 and on
day 28 was not significantly reduced compared to the solvent control. On
day 28 increasing nitrate concentrations were observed with increasing
test item concentrations up to 128 mg/kg soil dw. At 512 mg/kg soil dw
the nitrate concentration was comparable to the solvent control.
Therefore the LOEC and NOEC were considered to be >512 mg/kg soil dw and
≥512 mg/kg soil dw, respectively.
Due to the lack of adverse effects on nitrate concentration in soil ECX
values could not be determined. The EC50 is assumed to be higher than
the highest tested concentration of 512 mg a.s./kg soil dw
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