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EC number: 248-948-6
CAS number: 28299-41-4
In 2 valid skin irritation studies, ditolylether was found as
slight/moderately irritating (Maertins, Suberg) to the skin, whereas a
study with a semiocclusive application of the test substance over 24
hours at the inside of a rabbit ear found the test item highly
irritating to the skin.
2 valid eye irritation studies stated ditolylether as not irritating to
the eye (Maertins, Thyssen).
Method: 3 white New-Zealand rabbits were treated with 0.5 ml of
undiluted test substance. The test item remained under semiocclusion on
the skin for 4 hours. Treated animals were inspected for skin effects
(erythma, oedema) after removal of patches and after 1, 2, 3 and 7 days.
Total observation time was 7 days
Result: slightly irritating to the skin, but not sufficient for
Reference: Maertins (Bayer AG), 1989
This study reveals that the test substance does not have a significant
irritant potential on the eye.
Method: 100 µl test compound was instilled into the conjunctival sac of
one eye of each of 3 rabbits. the lids were then gently held together
for about one second. the other eye remained untreated and served as
control. the treated eye was washed out with physiological NaCl solution
24 hours after instillation of the test compound
Result: not irritating to the eye
Two valid studies conducted according to OECD TG 404 found ditolyl ether
to be not irritating according to GHS criterias. A study following no
guideline (24 h application, inside rabbit ear) reported irritating
observations of ditolylther but this method is known to overestimate
potential skin irritating effects.
In 2 valid studies ditolylether was not irritating to the eye.
The findings for skin irritation did not meet the criteria for
classification. Also for eye irritation a classification is not required.
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