Ditolyl ether

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientific acceptable and well documented

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Noakes and Sanderson (1969), Brit J Ind Med 26, 59

Principles of method if other than guideline:

Single cutan application of 2.5 ml of the test substance to 5 male and 5 female rats. post observation period was 14 days.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ditolyl ether

EC Number:

248-948-6

EC Name:

Ditolyl ether

Cas Number:

28299-41-4

Molecular formula:

C14H14O

IUPAC Name:

Benzene, 1,1'-oxybis[methyl-

Details on test material:

Baylectrol 4900, liqiud substance; density: 1.035 kg/liter (according LXS MSDS)

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

male + femaleWistar rats, SPF, ca. 9 - 14 weeks old, average weight of 179 g (males) and 152 g (females), husbandry: conventional in makrolon cages typ III

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

animals were inspected several times on the same day of the application of the test substance. During the post observation period of 14 days animals were inspected twice daily (daily on weekends) and time of onset, duration, and severity of clinical signs recorded

Duration of exposure:

4 or 24 h (according Noakes and Sanderson (1969), Brit J Ind Med 26, 59)

Doses:

2.5 ml per animal

No. of animals per sex per dose:

5 male + 5 female rats

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: During the post observation period of 14 days animals were inspected twice daily and time of onset, duration, and severity of clinical signs recorded, animals were weighened before, after 1 week and at the end of the post-observation period
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology

Statistics:

not applicable - all animals survived

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

discriminating dose

Effect level:

> 2 587 mg/kg bw

Mortality:

all animals survived

Clinical signs:

other: no symptoms of poisoning were observed

Gross pathology:

section of some animals killed at the end of the test showed no specific findings

Other findings:

no data

Any other information on results incl. tables

Single dermal exposure of rats to 2587 mg/kg bw: no symptoms of toxicity

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

Method: according Noakes and Sanderson (1969), Brit J Ind Med 26, 59; single cutan application of 2.5 ml of the test substance to 5 male an d 5 female rats. post observation period was 14 days

Result: LD50 > 2.5 ml/kg bw (2587 mg/kg bw), (rats, male + female); no deaths, no symptoms of poisoning were observed.

reference: Kroetlinger (Bayer AG), 1984