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EC number: 248-948-6
CAS number: 28299-41-4
All dose groups: no changes of the hematological,
pathological-anatomic, histopathological or ophthalmologic parameters.
5000 ppm : in the males body weight gain reduced by ca. 10 %; in both
sexes liver weights were increased, but Cytochrome P-450 and N-
or O-Demethylases not induced;
Clinical-chemical investigations: indications of a
treatment-related influence on the metabolism of proteins
(increased content of albumin
and decreased content of globulin in the serum) and indications of a
slight cholestasis (increased activities of the alkaline phosphatase in
Method: 10 male and female rats each were administered orally daily
doses of the test substance of 0 (control), 550, 1650 or 5000 ppm (ca.
0, 45, 132 or 425 mg/kg bw/d - male rats; ca. 0, 56, 174 or 604 mg/kg
bw/d - female rats) via diet. Mortality, clinical signs, food/water
intake, body weights were recorded and hematological, clinical
biochemistry determinations, and gross necropsy, histogpathylogy were
Result: the NOAEL = 132 mg/kg bw/day (male rats), NOAEL = 174 mg/kg
bw/day (female rats)
Reference: Kroetlinger, Schilde (Bayer AG), 1988
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