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EC number: 248-948-6
CAS number: 28299-41-4
In all dose groups, no indications of teratogenesis was observed. At 1000 mg/kg bw/d, there were signs of maternal toxicity (body weight gain reduced during the whole gestation; treatment-related deaths (mortality: 4/25)). Signs of embryotoxicity were reduced number and decreased weights of the fetuses at the high dose level.
Doses up to 300 mg/kg bw/g were tolerated without any signs of maternal toxicity and without toxic signs on embryonal and foetal development.
Method: 25 inseminated Wistar rats per group were orally administered daily doses of 0, 100, 300, and 1000 mg kg bw on days 6-15 of pregancy. dams were examined regarding body weight, appearance and behaviour. On day 20 of gestation dams were killed and the foetuses delivered by caesarean section were examined for morphological changes.
Result: NOEL = 300 mg/kg bw/day for maternal and embryonal/foetal toxicity
Reference: Renhof (Bayer AG), 1986
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