Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-948-6
CAS number: 28299-41-4
In all dose groups, no indications of teratogenesis was observed. At 1000 mg/kg bw/d, there were signs of maternal toxicity (body weight gain reduced during the whole gestation; treatment-related deaths (mortality: 4/25)). Signs of embryotoxicity were reduced number and decreased weights of the fetuses at the high dose level.
Doses up to 300 mg/kg bw/g were tolerated without any signs of maternal toxicity and without toxic signs on embryonal and foetal development.
Method: 25 inseminated Wistar rats per group were orally administered daily doses of 0, 100, 300, and 1000 mg kg bw on days 6-15 of pregancy. dams were examined regarding body weight, appearance and behaviour. On day 20 of gestation dams were killed and the foetuses delivered by caesarean section were examined for morphological changes.
Result: NOEL = 300 mg/kg bw/day for maternal and embryonal/foetal toxicity
Reference: Renhof (Bayer AG), 1986
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Niniejsza strona używa plików cookies, aby zapewnić optymalne korzystanie z naszych stron internetowych.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again