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EC number: 248-948-6
CAS number: 28299-41-4
no evidence was seen for a species difference in animals in the
metabolism of diphenyl ether
Metabolism of diphenyl ether was examined in rats, rabbits, and guinea
pigs. In the urine of these animals 4-hydroxydiphenyl ether was found as
main metabolite and in smaller amounts 4,4'-dihydroxydiphenyl ether,
both metabolites as free as well as conjugated substances. As additional
metabolites 2-hydroxydiphenyl ether, 4-methoxymonohydroxydiphenyl ether
and 4-methoxydihydroxydiphenyl ether was found in the urine of rats and
rabbits. Investigations with radiolabelled [14C]diphenyl ether indicated
a biological half-life of about 1.5 hours after i.g. application.
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