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EC number: 248-948-6
CAS number: 28299-41-4
After the 1. challenge with pure (100%) test compound 12 out of 20
animals of the test group revealed skin effects (score 1:
discrete/patchy erythema); the control group revealed no skin reactions.
After a 2. challenge with 10 or 50% test compound no skin effects were
Treatment was tolerated without systemic symptoms by all animals. No
death occured and body weight gain of the test group was identical with
the control group.
A pilot experiment was conducted to define the induction and challange
concentrations. After intradermal application of 5% compound erythema
and a white area arround the injection site was observed. After dermal
treatment of 4 animals 3/4 guinea pigs showed score 1erythema
(discrete/patchy erythema) indicating some irritation property of the
compound. No erythema was observed when control animal were topicall
challanged with 100% compound during the test.
In a Guinea Pig Maximization Test conducted according to OECD TG 406 and
GLP animals were dosed with irritating concentrations of the test
compound (5% for intradermal injection and 100% for topical
application). During challenge with the undiluted compound 12 out of 20
animals showed slight erythema (grade 1) after 48 hours and 2 out of
there animals showed slight erythema still after 72 hours. The remaining
10 animals showed no effect any more after 72 h. In a second,
subsequent, challenge with 10 or 50% compound after a 7 day rest, no
skin effects were observed in animals from the test or control group. No
skin reaction was observed in any control animal throughout the main
experiment. In a pilot experiment before the main experiment pure
compound (100%) was topically applied to 4 naïve guinea pigs to define
the topical induction and challenge dose for the main experiment. 3 out
of 4 guinea pigs showed scale 1 skin erythema reaction indicating that
pure compound has some irritation potential in guinea pigs. Overall, the
data indicate some dermal irritation and/or low dermal sensitization
potential of the compound.
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