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EC number: 201-174-2
CAS number: 79-07-2
Chloroacetamide was administered to mice by oral gavage
twice at an interval of 24 h at doses of 0, 1, 10, 100 mg/kg bw, next to
a positive control (Cyclophophamide 100 mg/kg bw).Six hours after the
second administration, the animals were sacrificed and the bone marrow
obtained from the femurs was processed, smeared on slides and stained.
Thereafter, normocytes and polychromatic erythrocytes of each animal
were examined for the ratio immature cells / normocytes as well as the
number of micronucleated normocytes and polychromatocytes.
Chloroacetamide did not result in a significant increase in the number
of polychromatic erythrocytes with micronuclei under the conditions of
the experiment; the number of micronucleated normocytes also did not
show substance related changes. The ratio normocytes/polychromatic
erythrocytes in male and female animals in all dose groups was
unaffected. The present result do not indicate an induction of
chromosomal mutations by Chloroacetamide.
Cyclophosphamide produced a significant increase in the
number of micronucleated polychromatic erythrocytes in male and female
animals. As an expression of the cytostatic effect of Cyclophosphamide
also the ratio normocytes/polychromatic erythrocytes was shifted in
favor of the mature cells.
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