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EC number: 201-174-2
CAS number: 79-07-2
Table 1. Results
Erythema (time after decontamination)
OVERALL MEAN ERYTHEMA (24, 48, 72h): 1.1
Edema (time after decontamination)
OVERALL MEAN EDEMA (24, 48. 72h): 0.5
A dorsal area of the trunk of approximately 25 cm2
of 3 rabbits was shaved ca. 24 hours before the start of the test
. Each animal (intact skin) was applied with 500 mg Chloroacetamide
(made into a paste with 0.25 mL of 0.9% NaCl solution). The mixed
substance was applied on a wound plaster with 2.5 X 2.5 cm cellulose pad
and the plaster strips were attached to the prepared skin site under a
semiocclusive bandage. After 4 hours exposure, the remaining test
substance was washed carefully with lukewarm tap water. Observations
were done at 30-60 minutes and at 24, 48 and 72 hours after removal of
the plaster. As there were some other findings in 1 animal (skin suface:
coarse scales, dry, rough), additional observation was done up to 7
days. All changes were reversible within 7 days. Althoug Chloroacetamide
was assessed as slightly irritating, there is no reason for
The Skin irritation test in rabbits has shown that
Chloroacetamide according to the present study is assessed as slightly
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