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EC number: 201-174-2
CAS number: 79-07-2
Acute dermal toxicity of Chloroacetamide was tested
in 5 male and 5 female Sprague-Dawley rats at a dose of 2000 mg/kg bw
under occlusion. At the end of the dermal exposure period of 24 hours
the bandage was removed and the treated skin area washed with warm water
in order to remove any unabsorbed remnants of the test substance. The
observation period after the dermal administration lasted for 14 days.
No deaths and no symptoms occurred. The skin of the
animals showed no signs of irritation. Three female animals showed a
disturbance of body weight gain during the first week of the study,
which returned to normal until the end of the study. In all other
animals development of body weight was not impaired. The animals killed
at the end of the observation period showed no macroscopically visible
Based on the results obtained in this study the acute dermal LD50 of
Chloroacetamide for male and female rats is greater than 2000 mg/kg body
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