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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

pKa at 20°C:

Additional information

In the Klimisch 2 non-GLP study from Gries (2012) the pKa-values of Chloroacetamide were calculated using the online software tool SPARC(v4.6 (October 2011 release w4.6.1691 -s4.6.1687)). In the Guidance on information requirements Chapter R.7a: Endpoint specific guidance (May 2008) section R. Evaluation of available information on dissociation constant, page 176 it is stated that " ... it is recommended that SPARC be used". Since an international accepted QSAR tool was used this study was considered to be a Klimisch 2 study. The calculations were performed for 20°C.

The calculated pKa values were all far out of the environmentally relevant range, i.e., -4.56, -2.43 and 13.27. Therefore, these QSAR data are considered as acceptable for the further assessment of the test substance without further testing.