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EC number: 201-174-2
CAS number: 79-07-2
Klimisch 1 GLP study from Schneider (2001) the water solubility of
Chloroacetamide was determined using by HPLC following OECD 105 and EU
method A.6 using the flask method. Three flasks were placed into a water
bath at 30°C in 24 hour increments. The test solutions with about 380 g/L were
stirred continuously at this temperature. After 72 hours, the
temperature was changed to 20°C and the test solutions were kept for
another 24 hours. The test solutions were filtered prior to analysis.
Each solution was analysed twice by HPLC. A dependence of the measured
saturation concentrations on the time to equilibration was not observed.
Therefore all six values (three replicates, each measured twice) were
used for the calculation of the mean. The water solubility of
Chloroacetamide at 20°C was determined as 52.5 +/- 3.3 g/L.
of this study are considered reliable and relevant for the risk
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