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EC number: 201-174-2
CAS number: 79-07-2
In a 90 day oral repeated dose study in Wistar rats
were given doses of 0, 20, 100 and 500 mg Chloroacetamide test
substance/kg feed /day. Each group consisted of 10 male and 10 female
animals, of which the first 5 animals of each group, were killed at the
end of the 90 day, whereas the other 5 were killed after a 29 day
recovery period. In the high dose (500 mg/kg feed) male and female
animals showed reduced body weight gain and food consumption and
increased leucocytes in both sexes, decreased liver weights in females,
and smaller testes, reduced testicular weights, proliferation of
Leydig/other interstitial cells and depression - standstill of
spermiogenesis in males.Re-onset in the recovery group with partial to
complete regeneration of testes was observed in males, therefore this
was to be designated as reversible. Further liver weights were reversed
in females and slightly decreased in males in the hightest dose recovery
groups. The NOAEL was determined to be 100 mg/kg feed, which was
reported to correspond with 10 mg/kg bw/day.
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