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EC number: 201-174-2
CAS number: 79-07-2
48 hour EC50 Daphnia magna: 19.8 mg/L96 hour LC50 Enchytraus albidus: 8.9 mg/L
In the key
study from BASF, the acute toxicity of 2-chloroacetamide - which
contains at least 98% acitve ingredient - to Daphnia magna was
determined in a static GLP compliant test. The test was performed
according to EEC C.2 and OECD 202 without deviations to the guidelines. Since
the test was performed under GLP and the standard guidelines were
followed and the report is well documented, the study is scored as
was started with a control and nominal 5.8, 10, 18, 32, 58 and 100 mg
test item /L. Dose verification confirmed that the test solutions were
correctly applied and that the test material was stable throughout the
exposure period. Hence the obtained results can be based on nominal
concentrations. Four replicates with 5 daphnids < 24 hours were set up
at the start of the test.
hours of exposure, 0, 5, 0, 95, 100, 100 and 100 % of the daphnids were
immobilized at 0 (control), nominal 5.8, 10, 18, 32, 58 and 100 mg test
item /L, respectively. The corresponding 48 h EC50 value is 14 mg test
is considered to be acceptable for the risk assessment.
supporting study from Roembke et al (1989) they
a comparison study with the enchytraeid E. albidus with the aim to
compare the sensitivity of this organism with the sensitivity of Daphnia
magna. It is not mentioned that the tests were performed under GLP. The
study methods and the parameters for evaluation are clearly described.
The test procedures followed in general the procedures outlined in the
OECD 202 but the tests were extended to 96 hours. The results for
Chloroacetamid were not provided in detail. Only the LC50 value was
reported as 8.9 mg/L. For other chemicals more details on the results
(dose response curves) were provided. Based on this shortcoming, this
information on the toxicity of the test item on E. albidus is scored as
Klimisch 2. The
96 -hour LC50
of E. albidus for Choroacetamid was determined as 8.9 mg/L.
paper from Roembke et al (1989), the toxicity to D. magna was cited as
personal communication from Heimbach with an EC50 of 5.6 mg/L. Since no
experimental details were provided this information from Heimbach is
scored as Klimisch 4.
with E. albidus is considered to be acceptable for the risk assessment,
the EC50 for Daphnia magna reported in the same paper will not be used..
toxicity to daphnids as determined in the BASF study will be used for
the classification and labelling. The toxicity to E albidus will be used
for the risk assesment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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