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EC number: 201-174-2
CAS number: 79-07-2
Max. blood concentrations of 0.58 +- 0.22 µg
equivalent/ml between 2 and 6 h ( 4.4 +- 1.7 h) p. appl.
2-phase elimination from the blood with half-lives
of 5.7+-2.1 h (2-8h p. appl.) and 180+-35 h (up to 5 d p. appl.)
Groups of animals received single doses of
(1-14C)-chloroacteamide by the dermal pathway (onto shaved skin of the
back; oral intake from treated skin was prevented by fixing a vessel
onto the treated skin area). Treated skin areas were washed of 6 hrs
after substance administration. Parameters studied were absorption
(blood analysis), tissue distribution and excretion in urine and faeces.
Termination was after 24 hrs for dermal application. Radioactivity was
determined by liquid scintillation and whole-body autoradiography.
After dermal administration, maximal plasma levels were
observed between 2 and 6 hrs after application. Two elimination
half-lives of approximately 6 and 180 hrs were determined for blood.
Within 24 hrs, 43% of the administered radioactivity was excreted via urine,
whereas 0.7% of the administered radioactivity was excreted via faeces.
At study termination after 24 hrs radioactivity (33% of the applied
amount) was still present in organs, tissues, site of application and
remaining body. Autoradiography revealed that radioactivity was present
in blood, liver, kidneys and also in skin areas that had not been
treated. However, at 6 hours there was also clear radioactivity in
urinary tract, testes, lung and spleen. At study termination, 43.4% and
0.68% of the applied radioactivity had been excreted via urine and
faeces, respectively. 11.8% of the applied radioactivity was determined
in tissues and body compartments excluding treated skin areas, 21.1% of
the applied radioactivity was detected in skin of the application site.
In total, 77.5% of the applied radioactivity was recovered. Thus, from
the percentages of radioactivity excreted and radioactivity present in
body compartments different from the application site, 56% of the
applied radioactivity is taken as amount absorbed.
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