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EC number: 201-174-2
CAS number: 79-07-2
Groups of 10 animals received single doses of
(1-14C)-chloroacteamide by the oral pathway. Parameters studied were
absorption (blood analysis), tissue distribution) and excretion in urine
and faeces. Termination was after 7 days. Radioactivity was determined
by liquid scintillation and whole-body autoradiography. After oral
administration, maximal plasma levels were observed 1-3 hrs after
administration. Two elimination half-lives of 5.6 and 520 hrs were
determined for blood. Within 7 days after administration, 90% of
radioactivity was excreted via urine, whereas radioactivity in faeces
and cage wash amounted to 3.6%. At study termination after 7 d,
radioactivity could still be detected in plasma. Remaining total body
radioactivity after 7 days was 9% of the administered radioactivity.
Highest amounts were found in blood, heart, lungs, liver and spleen.
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