Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-002-1
CAS number: 102-06-7
Dermal absorption, distribution and metabolism of 1.3 -diphenylguanidine (DPG), widely used as an accelerator in processing rubber and in food packaging, was studied in adult female Sprague-Dawley rats. DPG shows 10% penetration through clipped back skin of the rats in 5 days. The first-order dermal absorption rate constant as determined by least square method was 0.021 +/- 0.002 d-1 (T1/2 = 33.6 days). Approximately 13% of the absorbed dose remained in the body in 5 days. Retention in skin, muscle, liver, intestine and fat contributed most to the body burden of DPG-derived radioactivity in 5 days. All tissues showed tissue to blood ratios greater than 1, with liver and intestine ratios of 26 at 5 days. Approximately 61% of the absorbed dose was eliminated into urine and 27% into feces in 5 days showing rapid clearance of absorbed DPG from the body. HPLC analysis of urine revealed two major peaks (parent compound and metabolite(s)). Within 72h, approximately 50% of the DPG-derived radioactivity excreted in the urine was parent compound. After 72h, the DPG-derived radioactivity in the urine was present in the form of a single metabolite, and no parent compound was detected. No parent compound was detected in feces. Two metabolites, neither of which occurred in urine, were detected in feces. The HPLC analysis of the radioactivity at the application site showed only parent compound.
Even though DPG shows slow dermal penetration, this route of exposure needs to be considered in the risk assessments besause of the suspected chronic toxicity of DPG.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again