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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
4.2 mg/L

Additional information

In a study performed by Bayer AG in 1970 the determination of the acute toxicity of DPG to golden orfes (Leuciscus idus) gave LC0 -72h = 1mg/l and a LC100 -48h = 10 mg/l. Nevertheless, this study is considered as not reliable due to the tested period (48h) which was shorter than the recommended exposure time period.

The acute toxicity of DPG (1,3-diphenlylguanidine) toOryzias latipeswas investigated using the Japanese Industrial Standard test (JIS K 0102 -1986 -71) (static or semi-static; 25°C +/- 2°C; solubilizer not specified). A LC50 of 10 mg/l was determined after a 48-h exposure. This study is considered as invalid due to significant methodological deficiencies.

A data sheet of the Monsanto Company (1986) contains the following information:

Pimephales promelas LC50 -96h = 4.2 mg/l

Lepomis macrochirus LC50 -96h = 9.6 mg/l

Salmo sp. LC50 -96h = 11 mg/l

Lastly, in an insufficiently documented study on Cyprinus carpio (single oral administration in gelatine capsule; flow-through system; 18°C), the following effects were observed by Loeb & Kelly (1963):

Dose in mg/kg bw

Effect / Test Duration

3.2; 6.0 and 8.7 mg/kg bw

no effects within 114 h

9.5 and 17 mg/kg bw

not specified symptoms after < 120 h, recovery after < 312 h

5.6 mg/kg bw

mortality after 71 h

9.5 and 70 mg/kg bw

not specified symptoms after >= 22 h, mortality after 125 h

Nevertheless, gavage of fish cannot be considered as relevant for aquatic ecotoxicological hazard assessment.