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EC number: 203-002-1 | CAS number: 102-06-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 4.2 mg/L
Additional information
In a study performed by Bayer AG in 1970 the determination of the acute toxicity of DPG to golden orfes (Leuciscus idus) gave LC0 -72h = 1mg/l and a LC100 -48h = 10 mg/l. Nevertheless, this study is considered as not reliable due to the tested period (48h) which was shorter than the recommended exposure time period.
The acute toxicity of DPG (1,3-diphenlylguanidine) toOryzias latipeswas investigated using the Japanese Industrial Standard test (JIS K 0102 -1986 -71) (static or semi-static; 25°C +/- 2°C; solubilizer not specified). A LC50 of 10 mg/l was determined after a 48-h exposure. This study is considered as invalid due to significant methodological deficiencies.
A data sheet of the Monsanto Company (1986) contains the following information:
Pimephales promelas LC50 -96h = 4.2 mg/l
Lepomis macrochirus LC50 -96h = 9.6 mg/l
Salmo sp. LC50 -96h = 11 mg/l
Lastly, in an insufficiently documented study on Cyprinus carpio (single oral administration in gelatine capsule; flow-through system; 18°C), the following effects were observed by Loeb & Kelly (1963):
Dose in mg/kg bw |
Effect / Test Duration |
3.2; 6.0 and 8.7 mg/kg bw |
no effects within 114 h |
9.5 and 17 mg/kg bw |
not specified symptoms after < 120 h, recovery after < 312 h |
5.6 mg/kg bw |
mortality after 71 h |
9.5 and 70 mg/kg bw |
not specified symptoms after >= 22 h, mortality after 125 h |
Nevertheless, gavage of fish cannot be considered as relevant for aquatic ecotoxicological hazard assessment.
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