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EC number: 202-476-7
CAS number: 96-09-3
In a reverse gene
mutation assay in bacteria, strains TA1535, TA1537, TA1538, TA100 and
TA98 ofS. typhimuriumwere exposed to Styrene Oxide dissolved in
ethanol at concentrations of 10 exp-4, 10 exp. -5, 10 exp. -6, 10 exp.
-7 , 10 exp. –8 , 10 exp. –9, 0 mol / plate in the presence and absence
of mammalian metabolic activation (liver S9 mix from rats induced with
Clophen) using the co-incubation method.
Styrene Oxide was
tested up to cytotoxic concentrations (10 exp-4 mol/plate). In strain TA
1535, a dose related increase to 357 (without metabolic activation) and
484 (with metabolic activation) revertants vs. 20 and 45 revertants in
control was observed. In strain TA 100, a dose related increase to 1111
(without metabolic activation) and 1165 (with metabolic activation)
revertants vs. 84 and 135 revertants in control was observed. There
was a concentration related positive response of induced mutant colonies
This study is
classified as acceptable. This study satisfies the requirement for Test
Guideline OPPTS 870.51001; OECD 471 for in vitro mutagenicity
(bacterial reverse gene mutation) data. The lack of a positive control
is acceptable as the test compound is clearly positive and thus
demonstrates adequate sensitivity of the test system.
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