Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-476-7
CAS number: 96-09-3
In a reverse gene
mutation assay in bacteria, strains TA1535, TA1537, TA1538, TA100 and
TA98 ofS. typhimuriumwere exposed to Styrene Oxide dissolved in
ethanol at concentrations of 10 exp-4, 10 exp. -5, 10 exp. -6, 10 exp.
-7 , 10 exp. –8 , 10 exp. –9, 0 mol / plate in the presence and absence
of mammalian metabolic activation (liver S9 mix from rats induced with
Clophen) using the co-incubation method.
Styrene Oxide was
tested up to cytotoxic concentrations (10 exp-4 mol/plate). In strain TA
1535, a dose related increase to 357 (without metabolic activation) and
484 (with metabolic activation) revertants vs. 20 and 45 revertants in
control was observed. In strain TA 100, a dose related increase to 1111
(without metabolic activation) and 1165 (with metabolic activation)
revertants vs. 84 and 135 revertants in control was observed. There
was a concentration related positive response of induced mutant colonies
This study is
classified as acceptable. This study satisfies the requirement for Test
Guideline OPPTS 870.51001; OECD 471 for in vitro mutagenicity
(bacterial reverse gene mutation) data. The lack of a positive control
is acceptable as the test compound is clearly positive and thus
demonstrates adequate sensitivity of the test system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again