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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: comparable to standards
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data List V
Author:
Smyth H F et al
Year:
1954
Bibliographic source:
Arch. ind. Hyg. occup. Med., 10, 61–68

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
no
Remarks:
study performed before implementation of GLP
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(epoxyethyl)benzene
EC Number:
202-476-7
EC Name:
(epoxyethyl)benzene
Cas Number:
96-09-3
Molecular formula:
C8H8O
IUPAC Name:
2-phenyloxirane

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: water, corn oil or 1% sodium 3,9-diethyl-6-tridecanol sulfate
Doses:
doses are not given in detail
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 4 290 mg/kg bw
95% CL:
3 070 - 5 980
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The oral LD50 is much higher than the maximum dose (2000 mg/kg bw) that is nowadays tested in acute toxicity studies.
Executive summary:

In an acute oral toxicity study, groups of 5 nonfasted, Carworth-Wistar rats weighing 90 to 120 g were given a single oral dose of Styrene Oxide at doses not reported in detail and observed for 14 days.

Oral LD50= 4290  mg/kg bw (95% C.I. 3070 - 5980)

Styrene Oxide is of LOW Toxicity, based on the LD50 in rats.