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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: comparable to standards
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data List V
Author:
Smyth H F et al
Year:
1954
Bibliographic source:
Arch. ind. Hyg. occup. Med., 10, 61–68

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
no
Remarks:
study performed before implementation of GLP
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(epoxyethyl)benzene
EC Number:
202-476-7
EC Name:
(epoxyethyl)benzene
Cas Number:
96-09-3
Molecular formula:
C8H8O
IUPAC Name:
2-phenyloxirane

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: water, corn oil or 1% sodium 3,9-diethyl-6-tridecanol sulfate
Doses:
doses are not given in detail
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 4 290 mg/kg bw
95% CL:
3 070 - 5 980
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The oral LD50 is much higher than the maximum dose (2000 mg/kg bw) that is nowadays tested in acute toxicity studies.
Executive summary:

In an acute oral toxicity study, groups of 5 nonfasted, Carworth-Wistar rats weighing 90 to 120 g were given a single oral dose of Styrene Oxide at doses not reported in detail and observed for 14 days.

Oral LD50= 4290  mg/kg bw (95% C.I. 3070 - 5980)

Styrene Oxide is of LOW Toxicity, based on the LD50 in rats.