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Registration Dossier
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EC number: 202-476-7 | CAS number: 96-09-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to standards
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data List V
- Author:
- Smyth H F et al
- Year:
- 1 954
- Bibliographic source:
- Arch. ind. Hyg. occup. Med., 10, 61–68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- study performed before implementation of GLP
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- (epoxyethyl)benzene
- EC Number:
- 202-476-7
- EC Name:
- (epoxyethyl)benzene
- Cas Number:
- 96-09-3
- Molecular formula:
- C8H8O
- IUPAC Name:
- 2-phenyloxirane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water, corn oil or 1% sodium 3,9-diethyl-6-tridecanol sulfate
- Doses:
- doses are not given in detail
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 290 mg/kg bw
- 95% CL:
- 3 070 - 5 980
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The oral LD50 is much higher than the maximum dose (2000 mg/kg bw) that is nowadays tested in acute toxicity studies.
- Executive summary:
In an acute oral toxicity study, groups of 5 nonfasted, Carworth-Wistar rats weighing 90 to 120 g were given a single oral dose of Styrene Oxide at doses not reported in detail and observed for 14 days.
Oral LD50= 4290 mg/kg bw (95% C.I. 3070 - 5980)
Styrene Oxide is of LOW Toxicity, based on the LD50 in rats.
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