Registration Dossier
Registration Dossier
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EC number: 202-476-7 | CAS number: 96-09-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication/study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of styrene oxide to styrene glycol by mouse liver and lung
- Author:
- Carlson G P
- Year:
- 1 998
- Bibliographic source:
- Journal of Toxicology and Environmental Health, Part A, 53:19–27, 1998
- Report date:
- 1997
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (epoxyethyl)benzene
- EC Number:
- 202-476-7
- EC Name:
- (epoxyethyl)benzene
- Cas Number:
- 96-09-3
- Molecular formula:
- C8H8O
- IUPAC Name:
- 2-phenyloxirane
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- mouse
- Strain:
- other: CD-1 and NSA
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: incubation with microsomes
- Vehicle:
- other: Tris buffer
- Details on exposure:
- Microsomes were prepared by ultracentrifugation and were incubated for 20 min in an incubation mixture containing 1 mM styrene oxide in 0.5 M Tris buffer with a total volume of 0.42 ml. Incubations were carried out at 37°C.
- Control animals:
- no
- Positive control reference chemical:
- no
- Details on study design:
- comparison of two mouse strains with respect to stereoisomers formed
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- R-enantiomer and S-enantiomer of styrene glycol
Any other information on results incl. tables
Liver |
Lung |
|||
Strain |
R |
S |
R |
S |
Racemic NSA CD-1 |
24.97 ± 1.97 26.66 ± 2.08 |
6.02 ± 0.93 10.34 ± 1.83b |
6.33 ± 0.56° 7.44 ± 0.71a |
0.96 ± 0.08a 1.32 ± 0.20a |
R-SO NSA CD-1 |
26.56 ± 3.23 36.32 ± 1.41b |
1.56 ± 0.31 2.22 ± 0.22 |
5.28 ± 1.00a 3.62 ± 0.68a |
1.83 ± 0.89 0.36 ± 0.11 |
S-SO NSA CD-1 |
0.84 ± 0.28 1.04 ± 0.05 |
51.16 ± 5.10 26.72 ± 7.97b |
0.61 ± 0.10 0.56 ± 0.10 |
10.49 ± 1.44a 9.09 ± 1.36a |
Note.Values are mean ± SE for five animals per group and are nmol styrene glycol formed/mg protein/min.
aSignificantly different (p< .05) from liver for same strain and enantiomer
bSignificant difference (p< .05) between strains.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
