Registration Dossier
Registration Dossier
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EC number: 202-476-7 | CAS number: 96-09-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication/study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of styrene oxide to styrene glycol by mouse liver and lung
- Author:
- Carlson G P
- Year:
- 1 998
- Bibliographic source:
- Journal of Toxicology and Environmental Health, Part A, 53:19–27, 1998
- Report date:
- 1997
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (epoxyethyl)benzene
- EC Number:
- 202-476-7
- EC Name:
- (epoxyethyl)benzene
- Cas Number:
- 96-09-3
- Molecular formula:
- C8H8O
- IUPAC Name:
- 2-phenyloxirane
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- mouse
- Strain:
- other: CD-1 and NSA
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: incubation with microsomes
- Vehicle:
- other: Tris buffer
- Details on exposure:
- Microsomes were prepared by ultracentrifugation and were incubated for 20 min in an incubation mixture containing 1 mM styrene oxide in 0.5 M Tris buffer with a total volume of 0.42 ml. Incubations were carried out at 37°C.
- Control animals:
- no
- Positive control reference chemical:
- no
- Details on study design:
- comparison of two mouse strains with respect to stereoisomers formed
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- R-enantiomer and S-enantiomer of styrene glycol
Any other information on results incl. tables
Liver |
Lung |
|||
Strain |
R |
S |
R |
S |
Racemic NSA CD-1 |
24.97 ± 1.97 26.66 ± 2.08 |
6.02 ± 0.93 10.34 ± 1.83b |
6.33 ± 0.56° 7.44 ± 0.71a |
0.96 ± 0.08a 1.32 ± 0.20a |
R-SO NSA CD-1 |
26.56 ± 3.23 36.32 ± 1.41b |
1.56 ± 0.31 2.22 ± 0.22 |
5.28 ± 1.00a 3.62 ± 0.68a |
1.83 ± 0.89 0.36 ± 0.11 |
S-SO NSA CD-1 |
0.84 ± 0.28 1.04 ± 0.05 |
51.16 ± 5.10 26.72 ± 7.97b |
0.61 ± 0.10 0.56 ± 0.10 |
10.49 ± 1.44a 9.09 ± 1.36a |
Note.Values are mean ± SE for five animals per group and are nmol styrene glycol formed/mg protein/min.
aSignificantly different (p< .05) from liver for same strain and enantiomer
bSignificant difference (p< .05) between strains.
Applicant's summary and conclusion
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