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EC number: 202-476-7
CAS number: 96-09-3
Acute toxicity data for styrene oxide are available for the oral, dermal and inhalation route.
In an acute oral toxicity study, groups of 5
nonfasted, Carworth-Wistar rats weighing 90 to 120 g were given a
single oral dose of styrene oxide at doses not reported in detail and
observed for 14 days.Theoral
LD50is 4290 mg/kg bw (95% C.I. 3070 - 5980).
In an acute dermal toxicity study, using the one-day cutt method
of Draize, groups of four male New Zealand giant albino rabbits
were exposed to the closely clipped fur to 1/10 of the body surface. The
dose retained beneath an impervious plaster film for 24 hours. Mortality
was considered complete after additional 14 days. The dermal LD50was
determined to be 1060 mg/kg bw(95%
C.I. 630 - 1790).
In an acute inhalation toxicity study, groups of 6 young adult
male Carworth-Wistar rats were exposed by inhalation route to vapours of
styrene oxide for 4 hours at concentrations of 500 ppm. Animals then
were observed for 14 days. At a concentration of 500 ppm 2 of 6 animals
died. The inhalatory LC50was determined to be 500 ppm,
corresponding to 2.45 mg/L (2450 mg/m³) for 4 hours.
Findings with respect to specific target organ toxicity are not
reported in neither of the publications.
Based on the results the following classification of styrene oxide
according to Directive 67/548/EEC and GHS Regulation EC No 1272/2008
with respect to acute toxicity is required.
Acute toxicity route
GHS Regulation EC No 1272/2008
LD50 4290 mg/kg bw
LD50 1060 mg/kg bw
Xn; R 21
LC50500 ppm vapour (2.45 mg/L)
Xn; R 20
* For the dermal route styrene oxide is subject to legal binding
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