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EC number: 202-476-7 | CAS number: 96-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Styrene oxide is known to be a genotoxic carcinogen; therefore testing on toxicity to reproduction has not to be performed according to REACH-VO Annex VIII 8.7.1 column 2 and Annex IX 8.7 column 2. Moreover, a relevant exposure to humans is excluded by handling styrene oxide exclusively under strictly controlled conditions according to Annex XI, article 3.
Short description of key information:
Further testing on fertility does not need to be conducted.
Effects on developmental toxicity
Description of key information
From available data there was no evidence for a teratogenic effect in rats or rabbits exposed to styrene oxide up to the lethal dose.
Additional information
Styrene oxide is known to be a genotoxic carcinogen; therefore testing on toxicity to reproduction has not to be performed according to REACH-VO Annex VIII 8.7.1 column 2 and Annex IX 8.7 column 2. Moreover, a relevant exposure to humans is excluded by handling styrene oxide exclusively under strictly controlled conditions according to Annex XI, article 3.
In order to fulfil completeness requirements, studies on reproductive toxicity need not to be conducted; however available data should be reported. The only available study on reproductive toxicity of styrene oxide in mammals has been published by Sikov et al. 1986.
This study is summarised in the IARC 1994 report as follows:
Only one study of the reproductive toxicity of styene-7,8-oxide in mammals has been published (Sikov et al. 1986). Six groups of at least 31 Wistar rats were exposed by inhalation (whole body) to 100 ppm (490 mg/m3) or 300 ppm (1470 mg/m3) styene-7,8-oxide (purity, 99%) vapour for 7 h per day either during a three-week (five days/week) pre-gestational period, during a three-week (five days/week) pre-gestational period and through days 1-19 of gestation, or on gestational days 1-19 only. A control group was exposed to air during the whole period. Fetuses were examined on day 21. There was extensive mortality among rats that received prolonged exposure to 100 ppm; exposure to 300 ppm was discontinued after one day because of mortality. Maternal weight gain was reduced in all groups receiving 100 ppm. Exposure only prior to mating had no effect on mating or fertility. Gestational exposure decreased the number of animals pregnant at term by increasing pre-implantation loss of embryos; fetal weights and lengths were reduced, and the incidences of retarded ossification of the sternebrae and occipital bones were increased.
In the same study, groups of 23-24 New Zealand white rabbits were exposed by inhalation to 0, 15 or 50 ppm (74 or 245 mg/m3) (measured concentrations, 14.6 and 51 ppm) styene-7,8-oxide (purity, 99 %) vapour for 7 h per day on days 1-24 of gestation. Fetuses were examined on day 30. Maternal toxicity was observed at the highest dose only, resulting in increased mortality (19/24 versus 1/23 in controls and 4/24 at 15 ppm) and decreased food consumption and weight gain. There was no effect on the proportion pregnant at term, i.e. there was no marked pre-implantation loss, but there was an increase in post-implantation loss, with 0.25, 0.93 and 1.5 resorptions per litter in the control, low- and high-dose groups, respectively.
There was no effect on fetal weight, and no increase in the incidence of malformations was observed in either rats or rabbits.
Justification for classification or non-classification
Additional information
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