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EC number: 203-906-6
CAS number: 111-77-3
average daily water consumption of 7 ml per 40-g mouse, drinking water
concentrations of 0.25, 1.25 and 2.5% diethylene glycol monoethyl ether
(DEGEE) represented average daily intakes of approximately 440, 2200 and
4400 mg DEGEE/kg/day, respectively.
pertaining to reproduction of F1 control and high dose males are listed
in the following table. Corresponding
data for F0 animals were not available. Values are presented as mean +/-
Body weight (g)
34.7 +/- 0.7
34.2 +/- 1.1
Left testis/epididymis wt (mg)
174 +/- 7
172 +/- 6
Right testis wt (mg)
Right epididymis wt (mg)
Prostate wt (mg)
Seminal vesicle wt (mg)
Percentage motile sperm
Sperm concentration (no. sperm x10E3/mg caudal epididymis)
Percentage abnormal sperm (excluding tailless)
significantly different from 0% group at p<0.05
were not necropsied. Therefore, sperm parameters, histology and gonad
weights of these animals were not assessed.
In a two-generational study investigated the effects in reproduction and
fertility of 0%, 0.25%, 1.25%, and 2.5% 2 -(2 -ethoxyethoxy)ethanol in
drinking water. Male and female CD-1 mice were continuously treated for
1 week prior to mating and for a 14 week breeding period followed by a
21 day holding period when they were separated and housed individually.
There were two deaths among the male F0 animals treated at high dose and
small decreases in the mean body weights. The body weights of the F1
offspring exposed to 2.5% level were slightly depressed at birth, at
weaning and at 74 +/-10 days. 2 -(2 -ethoxyethoxy)ethanol did not have
adverse effects on fertility and reproductive performance despite a 34%
decrease in caudal epididymal sperm motility in the F1 males at 2.5%.
The highest dose also increased liver weight and decreased brain weight
in both sexes of the F1 generation. The NOAEL for F0 and F1 generations
can be established at 1.25% 2 -(2 -ethoxyethoxy)ethanol based on
systemic and reproductive (sperm motility) effects respectively
(equivalent to 2200mg/kg), and 2.5% for the F2 generation.
The substance 2 -(2 -ethoxyethoxy)ethanol is a very close analogue of
the test substance used in the study and this result can be considered
highly predictive of the toxicity of 2 -(2 -methoxyethoxy)ethanol.
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