Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-906-6
CAS number: 111-77-3
Statistically significant changes reported (standard deviation in
In a dermal sub-chronic toxicity study which followed the basic
requirements of a guideline study, guinea pigs were exposed occlusively
to 2 -(2 -methoxyethoxy)ethanol at doses of 40, 200 and 1000mg/kg for 13
weeks. Exposed animals showed decreased splenic weights in the high and
medium dose groups. Isolated but significant changes were also seen in
the high dose groups clinical chemistry (LDH level) and haematology
(MCHC level). Changes were seen in all animals urine chemistry (calcium
concentration) but this was attributed to be a secondary consequence of
the elimination of metabolites. Some minor fatty changes were seen in
the livers of some animals in all dose groups, but it was difficult to
explain the biological significance of these in the absence of any
changes to any other liver parameters (eg weight) and were therefore
considered to be of minimal significance. Based on this analysis, the no
effect level from this study is 40mg/kg, although the suspicion that
this is likely to be a very conservative finding (effects seen are not
very much more severe at 1000mg/kg) and the effects may not be 'adverse'
and certainly not 'significant toxic effects', facts that need to be
borne in mind in selecting appropriate assessment factors for the risk
characterisation. Synopsis: NOAEL (dermal, guinea pig) = 40mg/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again