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EC number: 203-906-6
CAS number: 111-77-3
Statistically significant changes reported (standard deviation in
In a dermal sub-chronic toxicity study which followed the basic
requirements of a guideline study, guinea pigs were exposed occlusively
to 2 -(2 -methoxyethoxy)ethanol at doses of 40, 200 and 1000mg/kg for 13
weeks. Exposed animals showed decreased splenic weights in the high and
medium dose groups. Isolated but significant changes were also seen in
the high dose groups clinical chemistry (LDH level) and haematology
(MCHC level). Changes were seen in all animals urine chemistry (calcium
concentration) but this was attributed to be a secondary consequence of
the elimination of metabolites. Some minor fatty changes were seen in
the livers of some animals in all dose groups, but it was difficult to
explain the biological significance of these in the absence of any
changes to any other liver parameters (eg weight) and were therefore
considered to be of minimal significance. Based on this analysis, the no
effect level from this study is 40mg/kg, although the suspicion that
this is likely to be a very conservative finding (effects seen are not
very much more severe at 1000mg/kg) and the effects may not be 'adverse'
and certainly not 'significant toxic effects', facts that need to be
borne in mind in selecting appropriate assessment factors for the risk
characterisation. Synopsis: NOAEL (dermal, guinea pig) = 40mg/kg
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