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EC number: 203-906-6
CAS number: 111-77-3
Results for 0 -24 and 24 -48 hour collection periods combined. Note that
the figure for DEG also includes the amount detected as glycolic acid,
since this is a known metabolite of DEG:
TOTAL RECOVERED (48hr)
The tables below show the amounts collected over the two different time
periods for the three different doses:
0 – 24hr
24 – 48hr
In a study to examine the metabolism 2 -(2 -methoxyethoxy)ethanol, SD
rats were given single oral doses of 500, 1000 and 2000mg/kg and the
urine collected over two 24 hour periods for analysis for a number of
expected metabolites. The dominant metabolite was 2 -(2
-methoxyethoxy)acetic acid, which accounted for 87 -95% of the original
dose. Unmetabolised 2 -(2 -methoxyethoxy)ethanol, the glucoronide
conjugate and diethylene glycol were also found in small quantities. In
addition, the metabolite methoxyacetic acid was found, the amount
accounting for 0.8 -1.4% of the dose of 2 -(2 -methoxyethoxy)ethanol
given, with the amount seeming to decline with increasing dose. This
demonstrates that oxidation of the hydroxyl function is the dominant
metabolic pathway but small amounts of the substance are metabolised by
cleavage of the ether linkage. The study also showed that around 98% of
the dose of 2 -(2 -methoxyethoxy)ethanol is eliminated within 24 hours
and that MAA half life increases significantly at very high dose, which
could explain the reproductive effects seen at very high dose through
build up of concentration.
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