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EC number: 203-906-6
CAS number: 111-77-3
A potentially ambiguous conclusion arises from a weak positive response
in the absence of S9 in the context of a negative response in the
presence of S9. Mutation frequencies were 1.75, 3.75 and 4.5 at the top
three doses tested (relative to controls) which produced levels of
toxicity of 87%, 75% and 40% respectively. Results can be considered
ambiguous when the mutatant frequency per viable cell is only 2 -3 times
control (especially in the context of the high toxicity). It should be
noted that the response is very weak on a molar basis (1umole induces
1.1 mutations per million survivors per hour of exposure compared to 812
for the positive control) and also that there is a lack of response in
the presence of S9 and a lack of functional groups associated with
genotoxicity in the absence of metabolism. When the relative suspension
growth compared to controls was greater than 50%, mutation frequencies
were the same as negative control levels.
In a mammalian gene mutation study in which the genotoxic potential of 2
-(2 -butoxyethoxy)ethanol was examined in vitro using the the L5178Y
TK+/- mouse lymphoma test, ambigous results were obtained in the absence
of metabolic activation. Mutation frequencies up to 4.5x those of the
solvent control were seen. These result was considered ambigous because
of the associated toxicity seen at the higher doses, the lack of
biological plausibility, the weakness of the response when expressed on
a molar basis relative to positive controls and the fact that the result
was clearly negative in the presence of metabolic activation. Because
of the structural similarity between this substance and 2 -(2
-methoxyethoxy)ethanol, particularly with respect to function groups and
their surrounding atomic environment, this result can be reliably
extrapolated to the latter.
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