Registration Dossier
Registration Dossier
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EC number: 203-906-6 | CAS number: 111-77-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Full study report available. Acceptably well documented. Not to GLP
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(2-methoxyethoxy)ethanol
- EC Number:
- 203-906-6
- EC Name:
- 2-(2-methoxyethoxy)ethanol
- Cas Number:
- 111-77-3
- Molecular formula:
- C5H12O3
- IUPAC Name:
- 2-(2-methoxyethoxy)ethanol
- Details on test material:
- Sample no: 47-116. No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hilltop farms
- Weight at study initiation: 200-300g
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Vapour was produced by passing air at 2.5 l/min through the sample and then into a 9 litre animal chamber (dynamic conditions).
- Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- nominal concentration only tested.
- Duration of exposure:
- 6 h
- Concentrations:
- Animals exposed to a saturated atmosphere of test substance at 20C
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Temperature: 24C.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 1.2 mg/L air
- Exp. duration:
- 6 h
- Remarks on result:
- other: Based on calculated maximum saturated vapour concentration.
- Mortality:
- None
- Clinical signs:
- other: None
- Body weight:
- With no control it is not possible to interpret the results. The females did appear to gain weight more slowly in first 7 days compared to days 7-14 and males.
- Gross pathology:
- None
- Other findings:
- No signs of toxicity were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance has a very low acute toxicity when tested by the inhalation route up to the saturated vapour concentration
- Executive summary:
In an acute toxicity study by the inhalation route, rats were exposed to the saturated vapour concentration of 2 -(2 -methoxyethoxy)ethanol for a period of 6 hours. This is estimated to be 1.2mg/l. No signs of toxicity were observed. Clearly, the substance has a low acute toxicity by the inhalation route.
Synopsis:
LC0 (6 hour, rat): >Saturated vapour pressure = 1.2mg/l
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