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EC number: 203-906-6
CAS number: 111-77-3
ORAL:Mouse, male: LD50=7128mg/kg (fasted animals), 8188mg/kg (fed animals)Rat, male: LD50=7128mg/kg (fasted animals), 12410mg/kg (fed animals), >5000mg/kgRat, male/female: LD50=9210mg/kg, ~6500mg/kg, 6700ml/kgGuinea pig, male/female: LD50=4160mg/kgCat: LD50>4080mg/kgRabbit; LD50=>4000mg/kg, 6.3g/kgINHALATION:LD50 greater than saturated vapour pressureDERMALRabbit, male: LD50=9404mg/kgRabbit: LD50=8980ml/kg (9284mg/kg)Guinea pig: LD50>10g/kg, LD50 5-8g/kg
A number of reliable studies plus supporting information are available
in multiple species for the acute oral toxicity of 2 -(2
-methoxyethoxy)ethanol. A well documented study which looked at both
fasted and unfasted animals showed that mice were more sensitive than
rats with fasted animals (not surprisingly) more sensitive than fed
animals. The lowest value seen was 7128mg/kg for fasted rats and mice.
The full results are shown in the key information field. Other studies
reported consistent figures for the LD50 in these two species. A single
value for the guinea pig of 4160mg/kg was reported in a reliable study
and this is used to derive the key parameter for the oral route.
There is one reliable study plus a supporting study which both that
acute toxicity by the dermal route is low. All the studies were in
rabbits. The key study showed a dermal LD50 of 9404mg/kg. The supporting
reports an LD50 of 9284mg/kg. The result from the key study is used as
the key parameter
The vapour pressure for 2 -(2 -methoxyethoxy)ethanol is very low. In an
acute toxicity study by the inhalation route, rats were exposed to the
saturated vapour concentration of 2 -(2 -methoxyethoxy)ethanol,
estimated to be 1.2mg/l, for a period of 8 hours. No mortality was
observed. Clearly, the substance has a low acute toxicity by the oral
route. Along with supporting data from other studies, there is
sufficient information available to conclude that there is no acute
hazard by the inhalation route.
The rat and mouse are the two species normally used for acute oral
toxicity classification. The values obtained for these species are
greater than the threshold for classification. Values for other species
also fall outside the range for classification.
Acute toxicity data by the dermal route clearly shows that the LD50 is
greater than the threshold for classification.
The low vapour pressure of the substance plus limited short term
exposure information available for the inhalation route shows that the
substance is of low toxicity by the inhalation route and does not meet
the criteria for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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