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EC number: 203-906-6
CAS number: 111-77-3
Short description of key information on bioaccumulation potential result:
Elimination: 98% eliminated in 24hrs, mainly as 2-(2
-methoxyethoxy)acetic acid in urine
Short description of key information on absorption rate:
Humans: 0.206mg/cm2/hr (damage ratio 3.2+/-1.8; control 1-2)
In a study to examine the metabolism 2 -(2 -methoxyethoxy)ethanol, SD
rats were given single oral doses of 500, 1000 and 2000mg/kg and the
urine collected over two 24 hour periods for analysis for a number of
expected metabolites. The dominant metabolite was 2 -(2
-methoxyethoxy)acetic acid, which accounted for 87 -95% of the original
dose. Unmetabolised 2 -(2 -methoxyethoxy)ethanol, the glucoronide
conjugate and diethylene glycol were also found in small quantities. In
addition, the metabolite methoxyacetic acid was found, the amount
accounting for ~1 -1.5% of the dose of 2 -(2 -methoxyethoxy)ethanol
given. This demonstates that oxidation of the hydroxyl function is the
dominant metabolic pathways but small amounts of the substance are
metabolised by cleavage of the ether linkage. The study also showed that
around 98% of the dose of 2 -(2 -methoxyethoxy)ethanol is eliminated
within 24 hours.
Other similar glycol ethers have been found to be metabolised similarly.
The absorption and elimination of radio-labelled 2 -(2
-butoxyethoxy)ethanol in rats was followed following 24hr dermal
occluded exposure. It was also established that the main route of
elimination is overwhelmingly via the urine and the metabolite 2 -(2
-butoxyethoxy)acetic acid. The glucoronidate conjugate was also found at
significant levels (5 -8%). Females appeared to absorb and therefore
excrete larger quantities than males and the dermal absorption rate was
estimated to be 0.73 and 1.46mg/cm2/hr for males and females
respectively. Washing studies showed that 90%+ of externally applied
substance could be removed after 5 minutes exposure by skin washing.
An in vitro dermal absorption study using human skin showed that 2 -(2
-methoxyethoxy)ethanol is able to pass through the stratum corneum at a
rate of 0.206mg/cm2/hr) and causes slight irreversible damage to the
skin. There was a lag time of less than 1 hour for the substance to
cross the skin and appear in the receptor fluid. An in vitro dermal
absorption study was carried out to assess the permeability of rat skin
to aviation kerosine. The permeability of the individual components of
the kerosine was assessed, including 2 -(2 -methoxyethoxy)ethanol which
was present at 8% by weight as an de-icer. This substance was is able to
pass through rat stratum corneum at a rate of 0.051mg/cm2/hr, a rate
which was 4x that of any of the hydrocarbon components identified. There
is a lag time of approximately less than 1 hour for the substance to
cross the skin and appear in the receptor fluid and no detectable levels
of the glycol ether were found in the skin afterwards. The first result
is more reliable as no other substances were present to potentially
confound the results and it is based on human skin. This result also
provided the higher (more conservative) result.
No formal toxicokinetic studies have been performed on 2 -(2
-methoxyethoxy)ethanol. However, the metabolism study did establish that
nearly all of the applied dose is excreted within 24 hours of exposure.
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