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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No quantitative data, no strutural nformation regarding the measured metabolites

Data source

Reference
Reference Type:
publication
Title:
Toxicity of and biological monitoring for 1,3-Diamino-2,4,6-trinitrobenzene and other nitro-amino derivatives of benzene and chlorobenzene
Author:
Watanabe, T.; Ishihara, N.; Ikeda, M.
Year:
1976
Bibliographic source:
Int. Arch. Occup. Environ. Hlth. 37,, 157-168 (1976)

Materials and methods

Objective of study:
other: development of a method for biomonitoring
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
A method for qualitative detection of test substance / metabolites was developed
GLP compliance:
no
Remarks:
predates GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-2,4-dinitrobenzene
EC Number:
202-551-4
EC Name:
1-chloro-2,4-dinitrobenzene
Cas Number:
97-00-7
Molecular formula:
C6H3ClN2O4
IUPAC Name:
1-chloro-2,4-dinitrobenzene
Details on test material:
no data, except the name
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
propylene glycol
Duration and frequency of treatment / exposure:
single injection
Doses / concentrations
Remarks:
Doses / Concentrations:
100µMol/kg bw ( 20,256 mg/kg bw
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
DNCB and/ or metabolites are excreted via uriine in the rat.

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
DNCB is excreted via urine in the rat.