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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: Case report
Adequacy of study:
supporting study
Study period:
1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: single case

Data source

Reference
Reference Type:
publication
Title:
Contact urticaria to DNCB
Author:
van Hecke, E; Santosa, S.
Year:
1985
Bibliographic source:
Contact Dermatitis 12 (5): 282 (1985)

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-2,4-dinitrobenzene
EC Number:
202-551-4
EC Name:
1-chloro-2,4-dinitrobenzene
Cas Number:
97-00-7
Molecular formula:
C6H3ClN2O4
IUPAC Name:
1-chloro-2,4-dinitrobenzene

Method

Ethical approval:
not applicable
Subjects:
1
Clinical history:
alopecia areata
Controls:
none
Route of administration:
dermal

Results and discussion

Results of examinations:
One 26 year old male developed contact urticaria after repeated dermal treatment with DNCB for alopecia areata.

Applicant's summary and conclusion