Registration Dossier
Registration Dossier
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EC number: 202-551-4 | CAS number: 97-00-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Methods described only in summary; no specific data for DNCB, no data for individual samples
Data source
Reference
- Reference Type:
- publication
- Title:
- Percutaneous absorption: On the relevance of in vitro data
- Author:
- Franz, T. J.
- Year:
- 1 975
- Bibliographic source:
- J. Invest. Dermatology 64: 190-195 (1975)
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Absorption through human skin in vitro using 14C labelled material, determination of total absorption
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chloro-2,4-dinitrobenzene
- EC Number:
- 202-551-4
- EC Name:
- 1-chloro-2,4-dinitrobenzene
- Cas Number:
- 97-00-7
- Molecular formula:
- C6H3ClN2O4
- IUPAC Name:
- 1-chloro-2,4-dinitrobenzene
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14 C
Test animals
- Species:
- human
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- acetone
- Duration of exposure:
- 60 h
- Doses:
- no exact data; 4 - 40 µg per skin sample
- No. of animals per group:
- not applicable
- Control animals:
- no
- Remarks:
- not applicable
Results and discussion
Percutaneous absorption
- Dose:
- see above
- Parameter:
- percentage
- Absorption:
- ca. 53 %
- Remarks on result:
- other: no data
- Remarks:
- no exact dose reported
- Conversion factor human vs. animal skin:
- human skin used
Any other information on results incl. tables
results are reported only as summary, no individual data
Applicant's summary and conclusion
- Conclusions:
- DNCB is absorbed readily through human skin in vitro.
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