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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

The results from a transformation/dissolution test (Rodriguez et al., 2012, see IUCLID section 4.8) showed that the test substance titanium carbide is practically not soluble in water or pH neutral media. It will therefore not be possible to obtain a solution of the test material in cell culture medium in order to perform in vitro genetic toxicity testing.

Link to relevant study records

Referenceopen allclose all

Endpoint:
in vitro gene mutation study in bacteria
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint:
in vitro gene mutation study in mammalian cells
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

The results from a transformation/dissolution test (Rodriguez et al., 2012, see IUCLID section 4.8) showed that the test substance titanium carbide is practically not soluble in water or pH neutral media. It will therefore not be possible to obtain a solution of the test material in cell culture medium in order to perform in vitro genetic toxicity testing.

Based on this information, no classification for mutagenicity according to Regulation (EC) 1272/2008 is warranted for the test substance.